Bone tissue engineering

We work to translate therapeutic solutions that address clinical needs in bone regeneration. Our research relies in the use of acellular and cell based complementary strategies to guide stem cell differentiation into osteogenic precursors. Our work has progressed to preclinical models of non-union bone defects and we have planned to start clinical phases with a cell therapy in late 2020. Our core technologies for bone regeneration aim to:

• Develop in vitro implantable bone grafts, using our in house developed Nanokick bioreactors to promote stem cells to differentiate into osteoblasts.
• Develop safe and effective delivery systems for osteogenic and vasculogenic growth factors (e.g. BMP-2, BMP-7, VEGF) using material-driven fibronectin fibrillogenesis that enhance the presentation of growth factors.