Biomaterials Seminars live agenda – Past seminars listed here
20/11/2018 Dr Sarah Snelling (NDORMS, Oxford)
Dr Sarah Snelling, NDORMS, University of Oxford. Biomaterial strategies for tendon repair. Despite advances in surgical techniques 40% of surgical repairs for rotator cuff tendon tears fail. Implanted biomaterials are inherently bioactive and have the potential to provide mechanical and biological support for tendon healing – therefore improving patient outcomes. This talk will discuss the electrospun patches and yarns, in development for first in man human trials for tendon repair at the University of Oxford. The effect of changing the biological functionalisation and diameter of electrospun fibres on the activity of tendon-relevant cells will also be shown. The talk will emphasise the importance of considering the activity of biomaterials throughout their in vivo lifetime and the necessity to use well definied tissue endpoints when developing and testing new biomaterials for tendon repair. Associate Professor Sarah Snelling (NDORMS, University of Oxford) studied biochemistry before completing a DPhil in the genetics and cellular biology of osteoarthritis. Her current research focusses on biomaterial-directed immunomodulation to drive non-fibrotic repair of diseased or injured tendons and other tissues. Her work aims to modulate the activity of the repertoire of cells present at the site of biomaterial implantation. Associate Professor Snelling is keen to improve the translational pathway of biomaterials. Her previous research on the pathobiology of osteoarthritis and tendon disease has established her expertise in the interaction of inflammatory and fibrotic pathways, and in the regulation of cell signaling in disease pathogenesis. https://www.ndorms.ox.ac.uk/team/sarah-snelling
06/11/2018 – Stylianos Sarrigiannidis
Stylianos Sarrigiannidis, PhD student at CeMi. “Collagen calcium phosphate devices for bone augmentation”
30/10/2018 – Dr Sohini Kar-Narayan, University of Cambridge
Talk title: “Electromechanically interfacing with biology using piezoelectric nanomaterials and devices”
Talk summary: Biological systems are responsive not only to chemical changes, but also changes in their mechanical environment. This ‘mechanobiology’ is believed to regulate some important cell functions, such as how stem cells differentiate and the direction in which brain cells can grow. Electrical signals are also fundamental in the development of our biology, and the influence of mechanical as well as electrical stimulation on bone, muscle and nerve cells is significant and well documented, though often not well understood. In this talk Dr Kar-Narayan introduced a novel bio-electromechanical interfacing platform that her lab has developed based on piezoelectric polymer nanostructures. We use a template-wetting process to nanostructure the well-known bio-polymer poly-L-lactic acid so that it may provide both electrical stimulation (through the piezoelectric effect) and appropriate mechanical signaling (through high aspect ratio nanostructures) while retaining its biocompatible properties. Furthermore, this fabrication method also enables aerosol-jet printed electrodes to be embedded within the structure to allow targeted, local physical and electrical stimulation of cells. The implications for tissue engineering are demonstrated with human dermal fibroblast (HDF) cell attachment, proliferation and phenotype.
23/10/2018 – Sam Donnelly
Sam Donnelly, PhD student at CeMi. “Using PEG hydrogels and MSCs to create a 3D bone marrow niche to support HSCs in vitro”
09/10/2018 – Shijoy Mathew
Shijoy Mathew, PhD student at CeMi. “Manipulation of MSC differentiation using gold nanoparticle mediated microRNAs”
02/10/2018 – José Manuel Rey
Jose Manuel Rey, PhD student at CeMi. “Collagen microgels for regenerative medicine”
24/09/2018 – Dr Paul Reynolds, University of Glasgow
Dr Paul Reynolds (Prof Nikolaj Gadegaard lab at the School of Engineering, University of Glasgow. Talk title: “Anomalous diffusion on nanostructured surfaces”
18/09/2018 – Gergely Simon, Marco Cantini
Gergely Simon (Dr Ann Bernassau lab in Herrior Watt Uni, Edinburgh, co-supervised by Dr Mathis Riehle), “Acoustic separation of particles and cells in microfluidic devices”
Dr Marco Cantini
29/05/2018 – Wich Orapiriyakul, Sam Donnelly
Wich Orapiriyakul, PhD student at CeMi. “Nanovibrational stimulation (Nanokicking) for 3D osteogenesis in biphasic scaffolds; compositing of freeze dried collagen sponges with MSC seeded hydrogels for bone tissue engineering”
Sam Donnelly, CeMi. “Using polymer surfaces and polyethelene glycol hydrogels along with mesenchymal stem cells to produce an in vitro haematopoietic stem cell niche”
22/05/2018 – Hyeree Park, Eva Barcelona, Michaela Petaroudi
Hyeree Park, McGill University, Montreal, Canada. “Functionalisation of Injectable Dense Collagen”
Eva Barcelona, PhD student at CeMi. “Engineering surface mobility to control stem cell differentiation”
Michaela Petaroudi, PhD student at CeMi. “Bacterial engineering for the ex vivo expansion of Hematopoietic Stem Cells”
15/05/2018 – Laila Damiati, Katie Douglas
Laila Damiati, PhD student at CeMi. “Role of Implant Nanoroughness and Bioactive Coating on Osseointegration and Bacterial Growth”.
Katie Douglas, PhD student at CeMi. “Investigating Dormancy and Awakening of Pancreatic Cancer using Tunable 3D Hydrogels”
02/05/2018 – Professor Albert Folch, University of Washington
Talk title: “Digital Manufacturing of Microfluidic Devices”
Talk summary: Digital Manufacturing (DM) – of which 3D-Printing is an example – has been applied with great success to improve design efficiency and part performance in the automobile industry, aeronautics, microelectronics, architecture, sportswear, and biomedical implants, among others. However, by comparison with other manufacturing fields, microfluidics has been slow to adopt DM. Microfluidic chips are still designed largely from scratch, the materials (usually thermoset or thermoplastic polymers) are often manually poured into a mold to form 2D-layer replicas, and the mold replicas are manually aligned and bonded to form the final device. The production of microfluidic devices by micromolding, while being optimized for mass manufacturing, cannot be optimized at the same time for design variety. These limitations are difficult for researchers to assimilate because micromolding has been the prevalent mode of microfluidics manufacturing for over two decades. On the other hand, the economics of DM are well-suited for microfluidics because, as opposed to molding approaches, the cost per device does not scale up with its 3D complexity (“complexity is free”) and is insensitive to the size of the production batch, i.e. DM is ideal for project customization (“variety is free”). We are developing microfluidic devices through stereolithography (SL), a form of 3D-Printing, in order to make microfluidic technology readily available via the web to biomedical scientists. We have developed microfluidic devices by SL in PEG-DA-based resins with automation and biocompatibility ratings similar to those made with PDMS.
GLORI was founded in 2009 by MD Mr Dominic Meek and Prof Matt Dalby to encourage collaboration between between the basic sciences, applied sciences, engineering and clinic. The focus of this biannual event is to discuss research ideas and their potential clinical translation to deliver the next-generation of orthopaedic care. It combines expertise from orthopaedic surgeons, biologists, engineers and chemists from Glasgow and Strathclyde Universities.