The University of Glasgow

Centre for the
Cellular Microenvironment

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Brillouin Microscope

  • OLYMPUS DIGITAL CAMERA

    The Brillouin microscope enables label-free, non-contact mechanical property mapping using Brillouin light scattering spectroscopy. The system provides high-resolution, three-dimensional imaging of mechanical properties in biological and soft material samples without physical indentation, staining, or mechanical perturbation.

     

     

     

    By detecting frequency shifts in scattered laser light arising from intrinsic acoustic vibrations within the sample, the platform generates quantitative mechanical contrast related to elasticity and viscoelastic properties. Advanced spectrometer design ensures high spectral resolution, strong background suppression, and sensitive detection of weak Brillouin signals, enabling precise and reproducible mechanical mapping.

    The system is particularly well suited for live-cell studies, tissues, organoids, hydrogels, and other mechanically heterogeneous soft materials.

     

     

    Key capabilities:

    The platform supports high-resolution mechanical imaging with the following capabilities:

    • Label-free, non-contact mechanical imaging
    • Quantitative mapping of elasticity and viscoelastic properties
    • Three-dimensional mechanical contrast imaging
    • High spectral resolution and sensitivity for precise characterisation
    • Rapid acquisition for spatially resolved mechanical profiling