ZEISS LSM 980 (Airyscan 2) & LSM 900 Confocal Microscopes

• The facility houses two advanced laser scanning confocal microscopy platforms: the ZEISS LSM 980 equipped with Airyscan 2 and the ZEISS LSM 900 with Airyscan. These systems provide high-resolution, multi-channel fluorescence imaging for a broad range of biological and materials science applications.

  LSM 980 with Airyscan 2

  The LSM 980 incorporates Airyscan 2 detector technology, delivering enhanced sensitivity, improved signal-to-noise ratio, and resolution beyond conventional confocal limits (~1.7× improvement in lateral resolution). Airyscan 2 enables fast super-resolution imaging while maintaining low phototoxicity, making it particularly suitable for live-cell and dynamic studies.

  A key feature of the LSM 980 is its extended infrared (IR) detection capability, which enables deeper imaging of thick or highly scattering specimens and improved detection of far-red and near-infrared fluorophores. This makes the system particularly advantageous for 3D tissue imaging, organoids, cleared samples, and complex biomaterials.

  Laser lines: 405, 445, 488, 514, 561, 639, 730 nm

  Objectives: 5×, 10×, 20×, 40×, 63×

   

  LSM 900 with Airyscan

  The LSM 900 is a high-performance confocal platform also equipped with Airyscan detection, providing enhanced resolution, optical sectioning, and improved signal sensitivity compared to conventional confocal imaging.

  The system offers flexible spectral imaging and is well suited for routine and advanced fluorescence applications requiring high-quality optical sectioning and super-resolution capability.

  Laser lines: 405, 488, 561, 640 nm

  Objectives: 10×, 20×, 40×, 63×, 100×

   

  Key Capabilities,

  Both platforms support:

  • Multi-channel fluorescence imaging
  • Large-area tile scanning (mosaic acquisition)
  • Independent focus adjustment for individual tile positions, enabling accurate imaging across uneven or extended samples
  • Live-cell imaging with temperature and CO₂ environmental control
  • 3D z-stack acquisition and volumetric reconstruction

  Imaging of cells, organoids, tissue sections, biomaterials, and engineered constructs